Copy Number Variation Microarray Service

CD Genomics is a world-leading company that can provide the best solutions for researchers in the field of microarrays in the field of biomedicine. We have extensive project experience in microarray production and testing and can ensure that we provide the best products and services to customers around the world.

Genetic Variation

Genetic variations range from single nucleotide variations (SNP) to large structural variations (aneuploidy chromosomal rearrangements), which can help determine an individual’s unique susceptibility to disease. Detailed analysis of human SNPs found interesting SNP markers for certain diseases, but these small changes are not all. Different from the diversity of gene sequence represented by SNP, structural variation includes a variety of changes, such as duplication, deletion, and inversion. Copy number variation (CNV) can represent the structural variation of genes and is an important parameter to characterize the gains and losses of genomic DNA sequences. CNVs are an important source of genetic diversity and can promote the rapid adaptive evolution and progress of heritable and somatic human diseases (such as cancer).

Approximately 180,000 CNVs are reported in the Genome Variants Database (DGV). SNP-based genome-wide association studies (GWAS) have identified a large number of genetic variants associated with human phenotypes or complex diseases. The mining of CNV data allows exploration of the genome to find sources of variation other than SNPs and may help us find the heritability missing in GWAS. Using array-based comparative genomic hybridization (CGH) technology, CNVs at multiple sites can be evaluated simultaneously to identify and characterize them. High-throughput platforms such as microarrays have been applied to genome-wide copy number loss. As the density of probes increases, microarray tools can provide more comprehensive CNV coverage and achieve more in-depth genotyping research.

Targeted Genotyping Service Based on SNP microarray

When whole-genome genotyping is impractical or unnecessary, targeted genotyping methods provide a cost-effective alternative. Targeted genotyping can save laboratory resources and cover rare variants more deeply. We provide microarray-based targeted genotyping solutions that can target exomes or focus on specific genes of interest for analysis.

The SNP microarray used in this service includes customized targeted genotyping panels and semi-custom panels for the analysis of human, plant, animal, microbial and model biological samples. Our targeted genotyping microarray service can analyze healthy/diseased/processed samples from humans, animals, plants and microorganisms. Sample types include but are not limited to blood, fresh or fixed tissue samples, and cultured cells.

Use PennCNV to demonstrate how to construct a copy number polymorphism region (CNPR).
Fig.1 Use PennCNV to demonstrate how to construct a copy number polymorphism region (CNPR). (Lin C F, et al. 2013)


The array-based CNV detection experimental method still provides the most effective and cost-effective method for global, high-resolution scanning of genome structural features.

Our CNV analysis service provides testing and analysis work starting from sample testing. This service is based on copy number variation analysis of SNP microarray and CGH technology. Our SNP microarray-based genome-wide genotyping service can be used to detect genetic variation, and the data generated can uncover potential CNVs that cause diseases or phenotypes. The microarray-based copy number analysis method provides a reliable and effective method for large-scale analysis. Customers can process multiple samples on a single microarray to conduct extensive investigations of genomic structural variations and accurately analyze chromosomal aberrations, such as amplifications, deletions, rearrangements, and loss of heterozygous neutral copies.

We provide human and non-human SNP genotyping chips for CNV analysis. This service also provides semi-customized microarray analysis. Our scientists can assist you in selecting and designing detection markers on the microarray to provide the largest genome coverage for optimal copy number analysis. Our service process includes sample reception and pretreatment, optional microarray customization, microarray detection and data harvesting, and bioinformatics analysis. Our characteristic data analysis provides data mining under a variety of software, including Birdsuite, dChip, Genotyping Console (GTC) and PennCNV.

Our CNV analysis service. - CD Genomics
Fig 2. Our CNV analysis service.

Our Features

CD Genomics provides CNV analysis services based on SNP microarray and CGH technology. We have an advanced microarray experiment platform, a professional team of scientists, and are committed to cooperating with researchers from all over the world. Customers can directly contact our employees and provide timely feedback on their questions. If you want to save valuable time and resources, please contact us for more detailed information.


  1. Carter N P. Methods and strategies for analyzing copy number variation using DNA microarrays[J]. Nature genetics, 2007, 39(7): S16-S21.
  2. Lin C F, Naj A C, Wang L S. Analyzing copy number variation using SNP array data: protocols for calling CNV and association tests[J]. Current protocols in human genetics, 2013, 79(1): 1.27. 1-1.27. 15.
  3. Zhang X, Du R, Li S, et al. Evaluation of copy number variation detection for a SNP array platform[J]. BMC bioinformatics, 2014, 15(1): 1-9.
Our products and services are for research purposes ONLY. We do not perform any private testing services that are not for laboratory use.

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