Microarray-based Toxicology Genomics Service

As a trusted supplier in the field of microarrays, CD Genomics is committed to designing and developing various effective biological microarray products and providing corresponding testing services. Our microarray detection platform provides a full range of microarray-based analysis services to help our customers reduce costs while using advanced technologies for related research. We are confident to provide you with high-quality products and high-quality services to accelerate the output of research results.

Toxicogenomics

Toxicology genomics is the study of gene expression caused by exposure to toxicants, which represents the response of cells and organisms to changes in the external environment such as toxic stimuli. The measurement of gene expression levels, when exposed to chemical substances, can not only provide information about the mechanism of action of the toxicant but also form the "genetic characteristics" from the pattern of changes in gene expression in vitro and in vivo. This gene expression feature can be used for rapid screening based on the similarity between unknown or suspected toxicants and known toxicants. Toxicology genomics is shifting to animal-free methods, so high-throughput molecular biology screening methods have great potential. Toxic genomics research hopes to use mRNA and protein expression technology to study chemical effects in biological systems. Using this technology, the toxic and side effects of drugs on cells can be detected. The mRNA of cells or tissues exposed to toxicant stimulation is collected and transformed into a labeled cDNA library. Use microarray detection and stain with appropriate dyes to visualize and then measure hybrid gene expression. In recent years, the application of toxicological genomics technology has been expanded from the toxicological evaluation of drugs, and aquatic toxicology and ecotoxicology that have passed animal evaluation have also been developed.

Fig 1. Gene expression analyses by microarray. (Lettieri T, et al. 2006)

Service

Our microarray-based toxicology genomics services are mainly aimed at evaluating the toxic and side effects of drugs in vivo and in vitro. The service process includes sample pretreatment, mRNA isolation and quality control, transcriptome library construction (cDNA synthesis), and label visualization. Then complete the microarray detection through our microarray detection platform (optional prefabricated microarray or custom printed microarray), collect data, and finally perform bioinformatics analysis. Our bioinformatics service team is composed of a group of graduates from prestigious schools, using supporting software to analyze the related induction/inhibition level patterns of gene expression, and the biochemical pathways involved/regulated. The service covers endocrine regulation-related reactions, metabolic-mediated and mechanism-based toxicity, immunotoxicity, liver toxicity, cardiotoxicity, neurotoxicity, and other target organ toxicity. It covers a wide range and has a wide range of applications. The application of in vitro toxicological effects and early design, and the application of in vivo toxicological verification to the latest stage.

Fig 2. Toxicology genomics service process.

Our Benefits

• Strong purpose. Applicable to the assessment of the toxicology of most drugs;
• Wide range of applications. It can be applied to the analysis of toxicological genomics in vivo and in vitro;

CD Genomics provides high-quality microarray tools and convenient detection services for genome toxicology analysis. We have a large team of scientists with a solid academic foundation and cooperate with researchers in basic biology and biomedical projects from all over the world. The advantage of choosing an analytical testing outsourcing testing service is that there is no need to consider any other costs (such as equipment and laboratory space), and it saves supervision or management. This advanced technology can quickly turn around and provide reliable results, thereby saving valuable time and resources. Please contact us for more detailed information.

References

1. Pennie W D, Tugwood J D, Oliver G J A, et al. The principles and practice of toxicogenomics: applications and opportunities[J]. Toxicological Sciences, 2000, 54(2): 277-283.
2. Denslow N D, Garcia-Reyero N, Barber D S. Fish ‘n’chips: the use of microarrays for aquatic toxicology[J]. Molecular Biosystems, 2007, 3(3): 172-177.
3. Lettieri T. Recent applications of DNA microarray technology to toxicology and ecotoxicology[J]. Environmental health perspectives, 2006, 114(1): 4-9.
4. Nuwaysir E F, Bittner M, Trent J, et al. Microarrays and toxicology: the advent of toxicogenomics[J]. Molecular Carcinogenesis: Published in cooperation with the University of Texas MD Anderson Cancer Center, 1999, 24(3): 153-159.