CD Genomics is committed to providing genomic microarray solutions to global customers in the field of microarrays. We have completed a large number of research projects related to genome analysis in cooperation with many scientific research institutions, universities, companies and non-clinical research organizations.
Genomics methods have changed the way we conduct biological and medical research. The advent of microarray tools makes it possible to measure most mRNAs, proteins, metabolites, protein-protein interactions, genome mutations, polymorphisms, epigenetic changes, and microRNAs in a single experiment. The data generated by these methods, together with the knowledge derived from their analysis, facilitates the overall understanding of gene expression. DNA microarray technology may be the most successful and mature method for high-throughput and large-scale genome analysis. This technology makes it possible to correlate physiological cell states with gene expression patterns to study disease progression, cell response to stimuli, and drug target identification. The current methodology for constructing genome arrays mainly uses genome cloning (BAC, PAC, and cosmids). The recent use of DNA microarrays in biomedical research is not limited to gene expression. DNA microarrays are used to detect single nucleotide polymorphisms (SNPs) in our genome, aberrations in methylation patterns, changes in gene copy number, alternative RNA splicing, and pathogen detection. High-quality arrays, standardized hybridization schemes, accurate scanning techniques, and robust calculation methods have established DNA microarrays for gene expression as a powerful, mature, and easy-to-use basic genome tool.
Fig 1.Strategies for the construction of genomic arrays. (Mantripragada K K, et al. 2004)
Microarray tools are used in genomics analysis and design of gene structure, genetic variation analysis, gene expression regulation and other aspects. Our genome microarray service provides genetic analysis of a variety of DNA microarrays. The microarrays we provide can be used for genomics analysis, including exon microarray, CGH microarray, CNV microarray, SNP microarray, and aptamer microarray. The process of our genomics analysis service is service project communication, experimental protocol submission, microarray testing, bioinformatics analysis and report submission. We will return the trust of customers with excellent product quality, and provide customers all over the world with the most satisfactory products and services.
Fig 2. Microarray-based genome analysis service process.
|The comparative genome hybridization (CGH) method has changed the whole genome analysis of cancer genetic variation, and the array-based CGH (aCGH) method has further improved the resolution of this technology. Our CGH service can detect small chromosomal imbalances and copy number variation (CNV), and accurately define their size and variant gene content. The main advantage of CGH is that it allows the detection of changes in the number of copies of DNA sequences in the entire genome in a single hybridization and maps these sometimes very complex changes to normal metaphase chromosomes.
|Chromosome microarray analysis (CMA) provides convenient and rapid detection for the most common chromosomal diseases and a large number of serious genetic diseases that cannot be detected by traditional chromosome analysis. Our chromosome microarray service detects the loss and increase of chromosomes in the entire genome by comparing the intensity of hybridization between sample DNA and control DNA.
|Aptamers are highly structured oligonucleotides with specific binding characteristics that can compete with antibodies to assist multiple analysis methods in the analysis of target and non-target molecules. Aptamer microarray technology overcomes the limitations of protein/antibody microarrays due to antibodies and gives full play to the advantages of DNA/RNA microarrays.
|Genome-wide genetic analysis services based on SNP microarrays can use SNP markers for genome-wide association studies. Our platform uses high-throughput microarray tools to automate genome-wide SNP typing analysis.
|SNP markers are valuable resources for genetic background analysis in breeding. We provide microarray-based targeted genotyping solutions that can target exomes or focus on specific genes of interest for analysis.
|The range of genetic variation includes SNP to large structural variation (copy number variation, CNV), which helps to determine the unique susceptibility of individuals to diseases. CNV can represent the structural variation of genes and is an important parameter to characterize the gains and losses of genomic DNA sequences. This service is based on copy number variation analysis of SNP microarray and CGH technology.
CD Genomics provides high-quality commercial, customized and semi-customized microarray products and analysis&testing services based on microarray products. Our microarray test platform has well-equipped laboratories and a team of highly qualified scientists, and we look forward to cooperating with customers all over the world. We have comprehensive design and production capabilities to provide broad and comprehensive services for academic and industrial research. If you are interested in our products and services, please contact us for more details