DNA/RNA Aptamer Microarrays

CD Genomics is a world-leading company that can provide the best solutions for researchers in the field of microarrays in the field of biomedicine. We have extensive project experience in microarray production and testing and can ensure that we provide the best products and services to customers around the world.

DNA/RNA Aptamer Analysis and Aptamer Microarrays

Aptamers are highly structured oligonucleotides with specific binding properties, which are selected from a combinatorial library of synthetic nucleic acids by an iterative process referred to as Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Aptamers have many advantages because they can compete with antibodies to assist in multiple analysis methods for target and non-target molecular analysis, such as biosensors, affinity capillary electrophoresis, and affinity chromatography. They have high applicability in the identification, separation and detection of various analytes, such as amino acids, drugs, metal ions, peptides, proteins and even cells. The characterization of the binding affinity and specificity of aptamer candidates is a key but challenging step in the discovery process because the throughput of traditional tools is usually low. However, by performing these assays on a microarray, characterization can be performed in a high-throughput parallel manner.

Aptamer microarray technology overcomes the limitations of protein/antibody microarrays due to antibodies and takes advantage of the advantages of DNA/RNA microarrays. Aptamers are fixed on the surface of the microarray and serve as probes for various substances. The aptamer microarray manufacturing technology can be divided into two categories. On the one hand, aptamers can be synthesized directly on the surface of the microarray through in-situ synthesis. The limitation of the in-situ synthesis of ready-to-use microarray is that it is impossible to purify the aptamer after synthesis. On the other hand, aptamers can be attached to the microarray after synthesis and purification, the so-called post-synthesis immobilization.

Schematic overview over different aptamer microarray formats.
Fig.1. Schematic overview over different aptamer microarray formats. (Witt M, et al. 2015)


Our DNA/RNA aptamer microarray service is a customized microarray service, customizing microarray products with suitable specifications and probe sets for customers, and then completing subsequent detection and analysis work through our microarray test platform.

Aptamer microarray service process. - CD Genomics
Fig 2. Aptamer microarray service process.

Technical advantages

  • The aptamer itself has characteristics superior to antibodies:
  • (1) Aptamers are much smaller than antibodies and can form a higher density affinity stationary phase on the surface of the microchannel;
    (2) Aptamers are easier to be modified at the terminal sites and have various functional groups, which makes them easier to fix on the support;
    (3) Aptamers are more stable than antibodies at room temperature and under harsh elution conditions (such as extreme pH, urea, organic solvents, chaotropic salts or other detergents);

  • Aptamers can specifically bind various targets from small organic molecules to supramolecular structures;
  • Aptamers have many advantages such as good stability, high affinity and strong specificity;

CD Genomics provides analysis services based on aptamer microarrays. We have an advanced microarray experiment platform, a professional team of scientists, and are committed to cooperating with researchers from all over the world. Customers can directly contact our employees and provide timely feedback on their questions. If you want to save valuable time and resources, please contact us for more detailed information.


  1. Witt M, Walter J G, Stahl F. Aptamer microarrays—Current status and future prospects[J]. Microarrays, 2015, 4(2): 115-132.
  2. Fischer N O, Tarasow T M. Identification and optimization of DNA aptamer binding regions using DNA microarrays[M]//Protein Microarray for Disease Analysis. Humana Press, 2011: 57-66.
  3. Xu Y, Yang X, Wang E. Aptamers in microfluidic chips[J]. Analytica chimica acta, 2010, 683(1): 12-20.
Our products and services are for research purposes ONLY. We do not perform any private testing services that are not for laboratory use.

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